Renal Cell Carcinoma - O 001
This section provides a listing of all trials that have been conducted within the SUO-CTC including trials that are in process for site selection, active patient recruitment, or closed to patient accrual.
Pending Site Selection
1.
UCM301
“Multicenter Phase 3 to Evaluate the Safety and Efficacy of TOOKAD (padeliporfin) Vascular Targeted Photodynamic Therapy Treatment of Upper Tract Urothelial Cancer; ENdoluminal LIGHT ActivatED Treatment of Upper Tract Urothelial Cancer (ENLIGHTED) Trial”
N= 70
(Sponsor: Steba Biotech UCM301)
SUO-CTC PI – Jonathan Coleman, MD, Memorial Sloan Kettering Cancer Center, New York, NY
Open to Patient Accrual
1.
CMN-001
“A Phase 2b Randomized Trial of Autologous Dendritic Cell Immunotherapy Plus Standard Treatment of Advanced Renal Cell Carcinoma”
N= 135
(Sponsor: CoImmune)
SUO-CTC PI – Gennady Bratslavsky, MD, SUNY Upstate, Syracuse, NY
Site Locations:
- MD Anderson
- Fox Chase Cancer Center
- H. Lee Moffitt Cancer Center
- Emory
- Mayo Clinic - Rochester
- Houston Methodist Hospital
- Westchester Medical Center
- University of Kansas Cancer Center
- SUNY Upstate
- Oregon Health Sciences University
Closed/Completed Accrual
1.
EA8143 PROSPER RCC
“A Phase 3 RandOmized Study Comparing PERioperative Nivolumab vs. Observation in Patients with Renal Cell Carcinoma Undergoing Nephrectomy”
N= 805 patients
(Sponsor: ECOG-ACRIN)
SUO-CTC PI – Gennady Bratslavsky, MD and Viraj Master, MD
Site Locations:
- Albany Medical Center
- Beth Israel Deaconess Medical Center
- Cedars-Sinai Medical Center
- Dana-Farber/Harvard Cancer Center
- Duke University Medical Center
- East Jefferson General Hospital
- Emory University Hospital/Winship Cancer Institute
- Fox Chase Cancer Center
- Geisinger Medical Center
- George Washington University Medical Center
- Hackensack University Medical Center
- Henry Ford Hospital
- Huntsman Cancer Institute/University of Utah
- Indiana University/Melvin and Bren Simon Cancer Center
- Johns Hopkins University/Sidney Kimmel Cancer Center
- Kaiser Permanente-Anaheim
- Kaiser Permanente-Fontana
- Kaiser Permanente-Oakland
- Lahey Hospital and Medical Center
- Lakeland Regional Health Hollis Cancer Center
- Lexington Medical Center
- Loyola University Medical Center
- LSU Healthcare Network / Metairie Multi-Specialty Clinic
- Maine Medical Partners — South Portland
- Massachusetts General Hospital Cancer Center
- Mayo Clinic
- Medical College of Wisconsin
- Montefiore Medical Center — Moses Campus
- Northwestern University
- NYP/Weill Cornell Medical Center
- Oregon Health and Science University
- Parkview Regional Medical Center
- Penn State Milton S Hershey Medical Center
- Prisma Health Cancer Institute — Eastside
- Rambam Medical Center
- Rush University Medical Center
- Rutgers Cancer Institute of New Jersey
- State University of New York Upstate Medical University
- Tulane University Health Sciences Center
- UC San Diego Moores Cancer Center
- UCLA / Jonsson Comprehensive Cancer Center
- UMass Memorial Medical Center — University Campus
- UNC Lineberger Comprehensive Cancer Center
- University of Alambama at Birmingham Cancer Center
- University of Arizona Cancer Center-North Campus
- University of California Davis Comprehensive Cancer Center
- University of Chicago Comprehensive Cancer Center
- University of Cincinnati/Barrett Cancer Center
- University of Colorado Hospital
- University of Florida Health Science Center — Gainesville
- University of Kansas Cancer Center
- University of Kansas Hospital-Westwood Cancer Center
- University of Michigan Comprehensive Cancer Center
- University of Missouri — Ellis Fischel
- University of Oklahoma Health Sciences Center
- University of Pennsylvania/Abramson Cancer Center
- University of Rochester
- University of Texas Health Science Center at San Antonio
- University of Vermont and State Agricultural College
- University of Vermont Medical Center
- University of Virginia Cancer Center
- University of Wisconsin Hospital and Clinics
- UT Southwestern Clinical Center at Richardson/Plano
- UT Southwestern/Simmons Cancer Center-Dallas
- UT Southwestern/Simmons Cancer Center-Fort Worth
- Vanderbilt University/Ingram Cancer Center
- Wake Forest University Health Sciences
- Wayne State University/Karmanos Cancer Institute
- William Beaumont Hospital — Troy
- William Beaumont Hospital — Royal Oak
- Yale University
Closed/Completed Accrual
2.
IMmotion010
“A Phase III, Multicenter, Randomized, Placebo-controlled, Double Blind Study of ATEZOLIZUMAB (Anti PD-L1 Antibody) as Adjuvant Therapy in Patients with PD-L1 Selected Renal cell carcinoma at intermediate to high risk of developing metastasis following nephrectomy”
N= 1000 global accrual
(Sponsor: Genentech/Roche)
SUO-CTC PI – Monty Pal MD, City of Hope, Duarte CA and Rob Uzzo MD, Fox Chase Cancer Center, Philadelphia PA
Site Locations:
- Banner MD Anderson Cancer Center
- Carolina Urologic Research Center
- Chesapeake Urology Research Associates
- City of Hope National Medical Center (Main)
- City of Hope National Medical Center (Satellite)
- Cleveland Clinic Foundation
- Columbia University Medical Center
- Emory University Winship Cancer Center
- Erlanger Health Systems
- Fox Chase Cancer Center
- Garden State Urology
- Levine Cancer Institute
- Loyola University Medical Center
- Mayo Clinic — Rochester
- Mayo Clinic — Scottsdale
- MD Anderson Cancer Center
- Moffitt Cancer Center
- Moores Cancer Center at UC San Diego Health
- Mount Sinai Medical Center
- NYU Langone Medical Center
- Ochsner Clinic
- Oregon Health and Science University
- Penn State Hershey Cancer Institute
- Stony Brook University Medical Center
- SUNY Upstate Medical University
- The Urological Institute of N.E. New York
- The Urology Center of Colorado
- Tulane University
- UCLA
- University of California Irvine Medical Center
- University of Chicago
- University of Colorado
- University of Florida
- University of Miami
- University of North Carolina
- University of Oklahoma
- University of Rochester Medical Center
- University of Texas Southwestern
- University of Utah; Huntsman Cancer Hospital
- UPMC Cancer Centers
- Urology Associates of Kingsport, P.C.
- Vanderbilt University Medical Center
- West Virginia University Hospitals Inc.
- Yale School of Medicine
Closed/Completed Accrual
3.
AGS 003-007
“An International Phase 3 Randomized Trial of Autologous Dendritic Cell Immunotherapy (AGS-003) Plus Standard Treatment of Advanced Renal Cell Carcinoma (ADAPT)”
N= 450 global accrual
(Sponsor: Argos Therapeutics)
SUO-CTC PI – Brian Lane MD, Spectrum Health, and Rob Uzzo MD, Fox Chase Cancer Center, Philadelphia PA
SUO-CTC contribution:
- 38% of Active Sites (50/130)
- 62% of Tumor Collections (N=712/1133)
- 61% of Patients Randomized to Treatment (N=284/462)
- 98% (49) of sites have contributed at least two nephrectomies
- 96% (48) have randomized at least one patient to therapy
- Patient Accrual January 2013 thru July 2015
- Multiple abstracts accepted for presentation
Closed/Completed Accrual
4.
“Sunitinib Treatment of Renal Adjuvant Cancer(S-TRAC): A Randomized Double-Blind Phase3 Study of Adjuvant Sunitinib vs. Placebo in Subjects at High Risk of Recurrent RCC – S-TRAC”
N= 720 global accrual
(Sponsor: Pfizer)
SUO-CTC was a late entry to the project to add to accrual:
- 5 SUO-CTC sites
- 10 patients accrued
- Patient accrual June 2010 thru February 2011