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Prostate Cancer Studies

This section provides a listing of all trials that have been conducted within the SUO-CTC including trials that are in process for site selection, active patient recruitment, or closed to patient accrual.


Open to Patient Accrual

1. “Prospective Validation of Prostate Biomarkers for Repeat Biopsy: The PRIORITY Study” N= 1000 global accrual (Sponsor: MDxHealth) SUO-CTC PI – Dan Lin MD, University of Washington Medical Center, Seattle WA

Site Locations:
  • Site selected by MDxHealth
  • SUO-CTC Principal Investitgator
  • Brigham and Women’s
  • Adam Kibel MD
  • Columbia University
  • Sven Wenske MD
  • Huntsman Cancer Institute/University of Utah
  • Will Lowrance MD
  • Johns Hopkins
  • Alan Partin, MD
  • New York University Medical Center
  • Samir Taneja MD
  • Ochsner Clinic Foundation
  • Daniel Canter MD
  • Ohio State University Medical Center
  • Ahmad Shabsigh MD
  • Tulane University Medical Center
  • Jonathan Silberstein MD
  • UC San Diego
  • Chris Kane MD
  • University of Chicago
  • Scott Eggener MD
  • University of Kansas Medical Center
  • Jeffrey Holzbeierlein MD
  • University of Michigan
  • Todd Morgan MD
  • University of North Carolina, Chapel Hill
  • Michael Woods MD
  • University of Oklahoma
  • Michael Cookson MD
  • University of Southern California
  • Sia Daneshmand MD
  • University of Texas Southwestern
  • Yair Lotan MD
  • University of Washington
  • Dan Lin MD
  • Vancouver Prostate Centre
  • Martin Gleave MD
  • Vanderbilt University
  • Sam Chang MD

Open to Patient Accrual

2. “A Randomized, Double-blind, Placebo-controlled, Phase 3 Study of Apalutamide in Subjects with High-risk, Localized or Locally Advanced Prostate Cancer Who are Candidates for Radical Prostatectomy” N= 350 from US sites; 1500 global accrual (Sponsor: Janssen Pharmaceuticals) SUO-CTC PI – Adam Kibel, MD, Brigham and Women’s, Boston MA

Site Locations:
  • Albany Medical College
  • Alliance Urology Specialists
  • Carolina Urologic Research Center
  • Carolina Urology Partners, PLLC
  • Dana Farber Cancer Institute
  • MDACC
  • Miami Cancer Institute at Baptist Health / Baptist Health Medical Group
  • Michigan Institute of Urology
  • Oklahoma City VAMC
  • Prisma Health
  • Regional Urology
  • SUNY Upstate Med Univ
  • UC Davis
  • UC Irvine
  • UCLA
  • University of Chicago
  • University of North Carolina
  • The Urology Center of Colorado (TUCC)
  • Urology of Virginia (UVA) - Virginia Beach (Devine-Tidewater Urology)
  • Urology Specialists LLC
  • Virginia Urology
  • Wichita Urology Group

Pending Site Selection

1. “An Evaluation of the Efficacy of Partial Gland Ablation (PGA) with TOOKAD® Vascular Targeted Photodynamic therapy (VTP) versus Active Surveillance for men with Intermediate Risk Localized Prostate Cancer.” N= 150 US patients from 15-20 sites (Sponsor: Steba Biotech)

Closed/Completed Accrual

1. PRO-IMPACT “PROspective Study of the IMPACT of a Genomic Test (Decipher™) on Physician and Patient Treatment Consideration and Decisions following Radical Prostatectomy [PRO-IMPACT] (CU-004)” N= 300 (Sponsor: GenomeDX) SUO-CTC PI – Dan Lin MD, University of Washington Medical Center, Seattle WA

SUO-CTC Contribution:

  • 94% of sites (18/19)
  • 94% of patients enrolled (269/284)
  • Arm A – 93% of patients enrolled (148/158)
  • Arm B – 96% of patients enrolled (121/126)
  • Patient Accrual - July 2014 thru February 2016
  • Multiple abstracts accepted for presentation

Closed/Completed Accrual

2. “Prevail - Phase III Placebo vs. Oral MDV3100 in chemo naïve patients with metastatic Prostate Cancer having failed ADT” N= 1680 global accrual (Sponsor: Medivation)

SUO-CTC was a late entry to the project to add to accrual:

  • 7 SUO-CTC sites o Accrual goal = 80
  • Screened = 86
  • Randomized = 56
  • Patient accrual December 2010 thru December 2011

Closed/Completed Accrual

3. “A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Abiraterone Acetate (CB7630) Plus Prednisone in Asymptomatic or Mildy Symptomatic Patients with Metastatic Castration-Resistant Prostate Cancer – AA302” N= 1000 global accrual (Sponsor: Cougar/Janssen) SUO-CTC PI – Allan Pantuck MD, UCLA Medical Center, Los Angeles CA

SUO-CTC was a late entry to the project to add to accrual:

  • 15 SUO-CTC sites
  • 95 patients accrued
  • Patient accrual April 2009 thru June 2010

Closed/Completed Accrual

4. “TITAN - A Phase 3 Randomized, Placebo-controlled, Double-blind Study of JNJ-56021927 Plus Androgen Deprivation Therapy (ADT) Versus ADT in Subjects with Low-volume Metastatic Hormone-sensitive Prostate Cancer (mHSPC) JNJ-56021927” N= 1000 global accrual (Sponsor: Janssen) SUO-CTC PI – Larry Karsh MD, The Urologic Center of Colorado, Denver CO

Site Locations:
  • Arizona Institute of Urology
  • Chesapeake Urology Research Associates
  • First Urology
  • Lancaster Urology
  • Michigan Institute of Urology
  • Montefiore Medical Center
  • Ochsner Clinic Foundation
  • Premier Medical Group
  • Ralph H. Johnson VAMC and Medical University of South Carolina
  • The Urology Center of Colorado
  • Tulane University School of Medicine - Tulane Cancer Center Comprehensive Clinic (TCCCC)
  • University Hospitals Case Medical Center
  • Urology Associates
  • Urology Centers Of Alabama
  • Urology of Virginia, PLCC
  • Urology San Antonio Research
  • Virginia Urology Center
  • W. G. ‘Bill’ Hefner VA Medical Center

Early Termination

1. “A Randomized Phase 2 Study of Cabozantinib (XL184) in Combination with Abiraterone in Chemotherapy-Naïve Subjects with Bone-Metastatic Castration-Resistant Prostate Cancer” N= 280 global accrual (Sponsor: Exelixis) SUO-CTC PI – Neal Shore, MD